III  The Laboratory Rodents

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Panting dogStudy Guide

  1. The Laboratory Chinchilla

Taxonomy:

The chinchilla is a larger rodent used in research.  Their classification is:

Kingdom Animalia
Phylum Chordata
Class Mammalia
Order Rodentia
Family Chinchillidae
Genus Chinchilla
Species Chinchilla laniger

In the wild, chinchillas live in the Andes mountains of Chile.  Their fur was very popular in the early 1900s because it is very soft and dense.  Overhunting decimated the population.  They are now listed an a threatened species and is protected by law in their native environment.  

The History of Chinchillas in Research:

All domestic chinchillas are descendents of 11 chins brought to the United States in 1927.  

The Role of Chinchillas in Research:

Chinchillas are most commonly used for auditory studies.  They are also used to study Chagas' disease, which causes heart failure in people.

Chinchilla Statistics:

Criterion

Chinchilla

Life Span 9 - 17 years
Adult Size 500 - 800 gm
Temperature 102 - 103° F
Pulse 200 - 350 bpm
Respirations 45 - 80 rpm
Estrous Cycle 30 - 50 days
Gestation 111 days
Weaning Age 3 - 8 weeks
 

The Anatomy and Physiology of Chinchillas:

The chinchilla has a stocky body with short delicate legs and rounded hairless pinna.  Chins have a bushy tail and a dense luxurious coat with up to 80 hairs growing from one follicle.  Their dorsum is usually bluish-gray and the belly is white.  They have prominent whiskers (up to 110 mm long) that they use for sensory input.  

Chins are rodents, and, therefore, are monogastrics with a large cecum.  Their oral cavity is small and narrow and their teeth are open-rooted.  The gastrointestinal tract is sensitive to antibiotics.   

Chinchilla Reproduction:

The female chinchilla (sow) has a prominent urinary papilla that can be confused with a penis, and a vaginal membrane except when in estrus and approaching parturition.  Female chins have three pair of mammary glands and are seasonally polyestrous from November through May.  The long gestation (111 days) results in a litter of 1 - 6 precocial pups.  The pups begin eating solid food when they are one week old, but should not be weaned for at least 3 weeks.

The smaller boar chinchilla has open inguinal canals and testes that are contained within the abdominal cavity.

Mating systems can be either monogamous or polygamous, although female chinchillas are monogamous in the wild.

Chinchilla Temperament:

Domesticated chinchillas are very social and hand tame readily.  Females are the dominant sex and may be aggressive toward other chins.  They are very active and acrobatic and like to climb.  The chinchilla has a flight response to danger.  

Technical Procedures on Chinchillas:

Chinchillas must be restrained carefully, supporting the abdomen and holding the base of the tail.  Fur slip may occur, with fur from anywhere on the body, including the tail, pulling out.  The fur will regrow and skin is not damaged.  

Chinchilla Husbandry:

Tall cages are preferred for chinchillas and dust should be provided for "bathing".  Because they are prone to hyperthermia, the temperature should be maintained between 50 - 68° F with humidity at 40% or less.

Chinchillas are omnivorous, feeding on vegetation, insects and bird eggs in the wild, but generally fed a grain-based complete pellet in the lab.  Extra fiber should be provided with alfalfa or timothy hay.  Like other rodents, chins are cecotrophic.

Chinchilla Health and Disease:

Chinchillas are susceptible to a variety of gastrointestinal disorders.

Enterotoxemia is associated with a variety of causes, including imprudent use of antibiotics.  Choke and bloat may result from blockage of the esophagus with treats, such as raisins or nuts.  Fur may form an obstruction in the stomach (trichobezoar) as a result of excessive grooming.

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  1. The Laboratory Guinea Pig

Taxonomy:

The guinea pig is a larger rodent used in research.  Their classification is:

Kingdom Animalia
Phylum Chordata
Class Mammalia
Order Rodentia
Family Caviidae
Genus Cavia
Species Cavia porcellus

In the wild, guinea pigs live in the Andes mountains of Peru, Venezuela and Chile.  They are raised for meat and were used in religious sacrifices by the South American Incas 

Guinea pigs breeds are based on coat length and color.  The most common pigs are shorthairs; the breed used for research is most commonly the Dunkin-Hartley albino shorthair.

Pet guinea pigs (often called "cavies") include:

  • Abyssinians (whorled medium length hair in rosettes

  • Peruvians (long silky hair parted in the center of the back

  • Skinny pigs (hairless)

  • Silkies  (long unparted soft hair)

  • Crested  (shorthair pigs with a single whorl on their forehead)

  • Texels  (long curly body hair with short hair on head)

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The History of Guinea Pigs:

Guinea pigs were domesticated by the Incas about 5000 BC.  Spanish Conquistadors and Dutch traders brought them from South America to Europe.  The origin of their name is unknown, but may be because they were exported from Guinea, they sold for a guinea (British coin) or they squeal like a pig.

The Role of Guinea Pigs in Research:

Guinea pigs have been used in research since 1780 and they are currently the 4th most popular laboratory animal, after mice, rats and rabbits.  Guinea pigs are used for studying many diseases and problems, including respiratory diseases, including asthma; immunology studies, including asthma and antibody production; nutritional studies, esp. for vitamin C deficiency (scurvy).

Guinea Pig Statistics:

Criterion

Guinea Pig

Life Span 4 - 8 years
Adult Size 700 - 900 g (F) 
900 - 1200 g (M)
Temperature 102 - 104° F
Pulse 250 - 350 bpm
Respirations 40 - 100 rpm
Estrous Cycle 15 - 17 days
Gestation 60 - 70 days  (ave 63 days)
Weaning Age 3 - 4 weeks

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The Anatomy and Physiology of Guinea Pigs:

Guinea pigs have stocky bodies with very short legs and they have no tail.  They are rodents, and, therefore, are monogastrics with a large cecum.  Their oral cavity is small and narrow and their teeth are open-rooted.  The gastrointestinal tract is sensitive to antibiotics.   

Guinea Pig Reproduction:

Sexing guinea pigs can be challenging, because the anogenital distance is similar and both males and females have two pair of mammary glands.  The female guinea pig (sow) has a Y-shaped vaginal opening and a vaginal membrane except when in estrus and approaching parturition. 

Female Guinea Pigs should be bred before she is six to eight months old, because her pelvis fuses about this age.  During normal parturition, hormones cause relaxing of the pelvic ligament, so the large pups can be delivered.  If the pelvis has fused, however, dystocia will result.

.The harem system is most frequently used by guinea pig breeders.

The Guinea Pig's long gestation (average 63 days) results in a litter of  precocial pups.  The pups begin eating solid food when they are one week old, but should not be weaned for at least 3 weeks.  

Guinea Pig Temperament:

Guinea Pigs are social, docile and rarely bite.  They are easily streseed, however, and may stampede or freeze when frightened.  Guinea pigs are vocal about any situation, especially the rustle of a cellophane bag containing food.

Guinea pig pups are much more active than their parents and jump like popcorn when they play. 

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Technical Procedures on Guinea Pigs:

Guinea Pigs must be restrained carefully, supporting theupper body with one hand and the hindquarters with the other.  Your grasp around the pig's thorax should be loose, so that it does not compromise the guinea pig's ability to breathe.  Scruffing is very difficult with guinea pigs, because there is little loose skin and the hair pulls out readily.

The Animal Welfare Act requires permanent identification for animals the size of a guinea pig or larger.  Identification methods include physical appearance, ear tags or notching, tattooing and microchips.

The ear vein or artery, the anterior vena cava and the saphenous veins are the most commonly used vessels for blood collection. 

Guinea Pig Husbandry:

Guinea pigs don't jump, nor are they able to climb out of cages.  They should be housed directly on the bedding.  Cage cleaning can be difficult, because guinea pig urine is high in minerals, which forms "scale" on the cage, and because guinea pigs produce large quantities of feces.  Group housing is preferred, because guinea pigs are herd animals.

Guinea pigs should be fed high quality commercial pellets.  Because guinea pigs do not produce vitamin C, food must be used within 3 months of milling date or the levels of vitamin C will be too low.  Some pigs are neophobic--they're very wary of new foods.  Like hamsters, guinea pigs have a blunt face, so make sure that they can obtain food from their feeder.  Supplementation with a grass hay is essential (to maintain gastrointestinal motility) and fresh fruits and vegetables are also recommended.

Guinea Pig Health and Disease:

Like chinchillas, guinea pigs are susceptible to a variety of gastrointestinal disorders, including Tyzzer's disease, salmonellosis and antibiotic-associated enteropathy.

All rodents have open rooted teeth, and guinea pigs are no exception.  They may develop malocclusion of incisors or molars.  When molars are affected, hyperptylism (drooling), anorexia and weight loss can occur.  

Guinea pigs are very susceptible to Bordetella pneumonia.  This bacterium is the cause of kennel cough in dogs and is also very common, but asymptomatic, in rabbits.  In guinea pigs, especially the young, this disease can cause dyspnea and death.  

Because of their inability to manufacture vitamin C, guinea pigs on poor diets may develop scurvy, with swollen painful joints, hemorrhage of mucous membranes and poor bone and teeth development.

Female guinea pigs are prone to reproductive maladies.  Dystocia can occur in females that are bred after their pelvic bones fuse.  She may also develop pregnancy toxemia during late pregnancy and during the first two weeks postpartum, especially if the sow is overweight or stressed.  It is very difficult to treat an affected sow; she usually dies, often after seizuring.

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09/17/03